Biological targets of isothiocyanates

Abstract

Background: Isothiocyanates are phytochemicals with a broad array of effects in biological systems. Bioactivity includes the stimulation of cellular antioxidant systems, induction of apoptosis and interference with cytokine production and activity. Epidemiological evidence and experimental studies indicate that naturally occurring isothiocyanates and synthetic derivatives have anti-cancer and anti-inflammatory properties. Scope of review: This review focuses on the molecular targets of isothiocyanates, and how target modification translates into a biological response. Major conclusions: Isothiocyanates may mediate their effects via direct protein modification or indirectly by disruption of r..