Stem Cells behind the Barrier
Michael Cangkrama, Stephen B Ting, Charbel Darido
International Journal of Molecular Sciences | MDPI AG | Published : 2013
Epidermal stem cells sustain the adult skin for a lifetime through self-renewal and the production of committed progenitors. These stem cells generate progeny that will undergo terminal differentiation leading to the development of a protective epidermal barrier. Whereas the molecular mechanisms that govern epidermal barrier repair and renewal have been extensively studied, pathways controlling stem cell differentiation remain poorly understood. Asymmetric cell divisions, small non-coding RNAs (microRNAs), chromatin remodeling complexes, and multiple differentiation factors tightly control the balance of stem and progenitor cell proliferation and differentiation, and disruption of this balan..View full abstract
We thank Stephen Jane for his critical reading and comments on this review. Stephen Ting is an NHMRC RD Wright Career Development Fellow and is funded by NHMRC grants. Charbel Darido is a Fellow of the Victorian Cancer Council and holds the Clare Oliver Memorial Fellowship for skin cancer research.