Journal article
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin
M Mlacki, C Darido, SM Jane, T Wilanowski
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal cadherin desmoglein 1 (Dsg1 ) in suprabasal layers of the epidermis. As a consequence, the epidermis of Grhl1-null mice displays fewer desmosomes that are abnormal in structure. These mice also exhibit mild chronic skin barrier defects as evidenced by altered keratinocyte terminal differentiation, increased expression of inflammatory markers and infiltration of the skin by immune cells. Exposure of Grhl1-/- mice to a standard chemical skin carcinogenesis protocol results in development of fewer papillomas than in wild type control animals, but with a rate of conversion to squamous cell carcinoma (SCC) t..
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Awarded by European Commission
Funding Acknowledgements
This work was supported by the European Molecular Biology Organization Installation Grant 2131 (http://www.embo.org/), the Marie Curie International Reintegration rant 256096 (FP7, EU)(http://ec.europa.eu/research/mariecurieactions/), the National Science Centre of Poland predoctoral grant 2011/03/N/NZ3/01957 (http://www.ncn.gov.pl/), supporting scholarship for PhD student in the Mazovia Region (Poland and European Social Fund, EU) (MM) (https://www.oeiizk.waw.pl/doktoranci/andhttp://ec.europa.eu/esf/), the National Health and Medical Research Council of Australia grant 628365 (http://www.nhmrc.gov.au/), the Association for International Cancer Research grant 11-0060 (http://www.aicr.org.uk/) and by the Victorian Cancer Agency Clare Oliver Fellowship (CD) (http://www.victoriancanceragency.org.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.