Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

CLONAL EVOLUTION IN MYELODYSPLASIA AND ACUTE MYELOID LEUKAEMIA FOLLOWING AZACITIDINE

The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) represent a spectrum of clinically heterogeneous malignancies that rema..

CIRCULATING TUMOUR DNA TO MONITOR TREATMENT RESPONSE AND RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKAEMIA

Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels o..

EPIGENETIC THERAPIES AS MOLECULAR PROBES TO INVESTIGATE THE MOLECULAR PATHOGENESIS OF LEUKAEMIA

A major limitation to the success of targeted therapies in cancer is the fact that we have few if any tools to study in detail their mechani..

EPIGENETIC REGULATION OF SELF RENEWAL AND LINEAGE COMMITMENT IN HAEMATOPOIESIS

The process by which all our mature blood cells are produced and sustained remains largely unknown. Underpinning the cell fate decisions mad..

CIRCULATING TUMOUR DNA AS A NONINVASIVE BIOMARKER IN MELANOMA

The expanding repertoire of treatment options in melanoma is bringing into focus the need for improved ways to accurately monitor treatment ..