When proteostasis goes bad: Protein aggregation in the cell

Surveillance of the mechanisms controlling proteome foldedness

This project aims to measure how cells keep the proteome folded. Cells have extensive quality control networks to govern synthesis, folding ..

PATHOGENIC AND ADAPTIVE MOLECULAR INTERACTIONS WITH MUTANT HUNTINGTIN EXON 1

This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene cre..

Defining the cellular impacts of protein aggregation in neurodegenerative disease with an aggreomics platform

The brain disease Huntington’s is caused by abnormally shaped proteins that assemble into toxic clusters. This project will design new biopr..

Role of Hsp40 and Hsp70 in huntingtin misfolding, oligomerization and inclusion assembly

Huntington disease results from a mutation that causes the Htt protein to become abnormally sticky and form toxic clusters in neurons. Cells..

Viewing the cellular responses in Huntington's disease through an aggreomics framework

Huntington disease results from a mutation that causes the Htt protein to form abnormal toxic clusters in neurons that eventually leads to c..