Journal article

Retinal biomarkers provide "insight" into cortical pharmacology and disease

Christine TO Nguyen, Flora Hui, Jason Charng, Shajan Velaedan, Anna K van Koeverden, Jeremiah KH Lim, Zheng He, Vickie HY Wong, Algis J Vingrys, Bang V Bui, Magnus Ivarsson

PHARMACOLOGY & THERAPEUTICS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

The retina is an easily accessible out-pouching of the central nervous system (CNS) and thus lends itself to being a biomarker of the brain. More specifically, the presence of neuronal, vascular and blood-neural barrier parallels in the eye and brain coupled with fast and inexpensive methods to quantify retinal changes make ocular biomarkers an attractive option. This includes its utility as a biomarker for a number of cerebrovascular diseases as well as a drug pharmacology and safety biomarker for the CNS. It is a rapidly emerging field, with some areas well established, such as stroke risk and multiple sclerosis, whereas others are still in development (Alzheimer's, Parkinson's, psychologi..

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