Journal article
A ceRNA hypothesis: The rosetta stone of a hidden RNA language?
L Salmena, L Poliseno, Y Tay, L Kats, PP Pandolfi
Cell | CELL PRESS | Published : 2011
Abstract
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer. © 2011 Elsevier Inc.
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
We thank all Pandolfi lab members for critical discussions. L. S. was supported by fellowships from the Canadian Institutes of Health Research and the Human Frontier Science Program. L. P. was supported by fellowships from the Istituto Toscano Tumori and the American Italian Cancer Foundation. Y.T. is supported by a Special Fellow Award from The Leukemia & Lymphoma Society. L. K. is supported by a NHMRC Overseas Biomedical Postdoctoral Fellowship. This work was supported by NIH grant R01 CA-82328-09 awarded to P. P. P.