Journal article

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

Yvonne Tay, Lev Kats, Leonardo Salmena, Dror Weiss, Shen Mynn Tan, Ugo Ala, Florian Karreth, Laura Poliseno, Paolo Provero, Ferdinando Di Cunto, Judy Lieberman, Isidore Rigoutsos, Pier Paolo Pandolfi

Cell | CELL PRESS | Published : 2011


Awarded by The Harvard Clinical and Translational Science Center (NIH)

Awarded by Italian Association for Cancer Research (AIRC)

Awarded by NIH

Funding Acknowledgements

We thank Pandolfi laboratory members for critical discussions. Real-time PCR analysis was conducted through the Harvard Catalyst Laboratory for Innovative Translational Technologies with support from Harvard Catalyst vertical bar The Harvard Clinical and Translational Science Center (NIH Award #UL1 RR 025758 and financial contributions from Harvard University and its affiliated academic health care centers). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, the National Center for Research Resources, or the National Institutes of Health. We thank B. Vogelstein for DICER<SUP>Ex5</SUP> cells, M. Gorospe for the pMS2 plasmids, and I. Legnini for experimental support. Y.T. was supported by a Special Fellow Award from The Leukemia & Lymphoma Society. L. K. was supported by an NHMRC Overseas Postdoctoral Fellowship. L. S. was supported by fellowships from the Human Frontier Science Program and the Canadian Institutes of Health Research. U. A. was supported by a fellowship from the Fondazione per la Ricerca Biomedica ONLUS of Torino. S. M. T. was supported by a Department of Defense (DOD) Breast Cancer Research Program (BCRP) postdoctoral fellowship award. P. P. and U. A. gratefully acknowledge support from the Italian Association for Cancer Research (AIRC) under grant IG-9408. I. R. was supported by funding from the Jefferson Medical College of Thomas Jefferson University. This work was supported, in part, by NIH grant R01 CA-82328-09 to P.P.