Journal article

Cell-Conditioned Protein Coronas on Engineered Particles Influence Immune Responses

Qiong Dai, Junling Guo, Yan Yan, Ching-Seng Ang, Nadja Bertleff-Zieschang, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2017

Abstract

A protein corona, which forms on engineered particles as soon as they are introduced into biological environments, is known to provide particles with a "biological identity". Protein coronas derived from various biological environments have been demonstrated to alter the cell internalization mechanism, to diminish targeting ability and to induce nanoparticle aggregation. So far, most of these studies have challenged engineered particles with a static biological environment. However, the extracellular environment is highly dynamic due to the process termed "cell-conditioning", in which cells deplete and secrete biomolecules. In this work, we demonstrate that protein coronas formed on engineer..

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC under the Australian Laureate Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030). Q.D. and J.G. acknowledge funding from the University of Melbourne through Melbourne International Research Scholarships. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).