Journal article

Regional differences in the expression of K -Cl- 2 cotransporter in the developing rat cortex

Krisztina Kovacs, Kaustuv Basu, Isabelle Rouiller, Attila Sik

Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2014


The type 2 potassium-chloride cotransporter (KCC2) is the main regulator of intracellular chloride concentration in CNS neurons, and plays a crucial role in spine development that is independent of its ion cotransport function. The expression pattern of KCC2 is upregulated during postnatal development showing area and layer-specific differences in distinct brain areas. We examined the regional and ultrastructural localisation of KCC2 in various areas of developing neocortex and paleocortex during the first two postnatal weeks. Light-microscopy examination revealed diffuse neuropil and discrete funnel-shaped dendritic labelling in the piriform and entorhinal cortices at birth. Subsequently, d..

View full abstract


Awarded by Canadian Institutes of Health Research

Awarded by Human Frontiers Science Foundation

Awarded by Medical Research Council

Funding Acknowledgements

The authors are grateful to Dr. Kai Kaila for critical reading of the manuscript. This work was sponsored by the Canadian Institutes of Health Research (MOP 81105), Human Frontiers Science Foundation (RGY-0073/2006) and Medical Research Council (G1001235) to A.S.