Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults.

Abstract

Chronic rhinosinusitis (CRS) is a common health problem which significantly affects quality of life. A wide range of medical and surgical therapies have been used to treat CRS. Both systemic and topical antibiotics are used with the aim of eliminating infection and inflammation, altering bacterial biofilm formation, reversing ostial occlusion and improving symptoms. Various groups of systemic antibiotics have been studied; clinical cure rates reported are inconsistent and range from 50% to 95%. To determine the effectiveness and adverse reactions associated with systemic antibiotic therapy for CRS in adults. We searched the Cochrane ENT Group Trials Register; CENTRAL (2010, Issue 2); PubMed;..