Pulmonary Vascular and Right Ventricular Reserve in Patients With Normalized Resting Hemodynamics After Pulmonary Endarterectomy
Guido Claessen, Andre La Gerche, Steven Dymarkowski, Piet Claus, Marion Delcroix, Hein Heidbuchel
Journal of the American Heart Association | WILEY-BLACKWELL | Published : 2015
BACKGROUND: Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, and the effect of sildenafil during exercise in these patients. METHODS AND RESULTS: Fourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (≤25 mm Hg) post-PEA underwent cardiopulmonary exercise testing, followed by cardiac magnetic resonance imaging with simultaneous invasive mPAP measurement during incremental supine cycling exercise. Peak o..View full abstract
This study was funded by a grant from the Fund for Scientific Research Flanders (FWO), Belgium. A. La Gerche was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC).