Condensin, master organizer of the genome
Paul Kalitsis, Tao Zhang, Kathryn M Marshall, Christian F Nielsen, Damien F Hudson
CHROMOSOME RESEARCH | SPRINGER | Published : 2017
A fundamental requirement in nature is for a cell to correctly package and divide its replicated genome. Condensin is a mechanical multisubunit complex critical to this process. Condensin uses ATP to power conformational changes in DNA to enable to correct DNA compaction, organization, and segregation of DNA from the simplest bacteria to humans. The highly conserved nature of the condensin complex and the structural similarities it shares with the related cohesin complex have provided important clues as to how it functions in cells. The fundamental requirement for condensin in mitosis and meiosis is well established, yet the precise mechanism of action is still an open question. Mutation or ..View full abstract
Awarded by National Health and Medical Research Council (nhmrc.gov.au) Australia Project
Awarded by Carlsberg Foundation Fellowship
This work was supported by the National Health and Medical Research Council (nhmrc.gov.au) Australia Project Grants GNT1069223, GNT1047009, a Carlsberg Foundation Fellowship CF15-0905, and the Victorian Government's Operational Infrastructure Support Program (vic.gov.au).