Journal article
Right ventricular and pulmonary vascular reserve in asymptomatic BMPR2 mutation carriers
G Claessen, A La Gerche, T Petit, H Gillijns, J Bogaert, M Claeys, S Dymarkowski, P Claus, M Delcroix, H Heidbuchel
Journal of Heart and Lung Transplantation | ELSEVIER SCIENCE INC | Published : 2017
Abstract
Background Non-invasive estimates have suggested that asymptomatic BMPR2 mutation carriers may have an abnormal pulmonary vascular response to exercise and hypoxia. However, this has not been assessed with “gold standard” invasive measures. Methods Eight controls and 8 asymptomatic BMPR2 mutation carriers underwent cardiac magnetic resonance imaging with simultaneous invasive pressure recording during bicycle exercise in normoxia, hypoxia and after sildenafil administration. Abnormal pulmonary vascular reserve was defined as an increase in mean pulmonary artery pressure relative to cardiac output (P/Q slope) >3 mm Hg/liter/min. Results During normoxic exercise, BMPR2 mutation carriers had a ..
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Funding Acknowledgements
[ "M.D. has served as investigator, speaker, consultant or steering committee member for Actelion, Bayer, Eli Lilly, GlaxoSmithKline, Pfizer and United Therapeutics, and has received research grants from Actelion, GlaxoSmithKline and Pfizer. H.H. is on the speakers' bureau and advisory board of Bayer, Boehringer-Ingelheim, Daiichi Sankyo, Bristol-Myers Squibb, Pfizer, Merck, Biotronik and St. Jude Medical.", "This study was funded by a grant from the Fund for Scientific Research Flanders (FWO), Belgium. A.L.G. was funded by a Career Development Fellowship from the National Health and Medical Research Council and National Heart Foundation of Australia (NHMRC and NHF)." ]