Journal article
Effect of respiration on cardiac filling at rest and during exercise in Fontan patients: A clinical and computational modeling study
A Van De Bruaene, G Claessen, A La Gerche, E Kung, A Marsden, P De Meester, S Devroe, J Bogaert, P Claus, H Heidbuchel, W Budts, M Gewillig
Ijc Heart and Vasculature | ELSEVIER IRELAND LTD | Published : 2015
Abstract
Background: Due to the absence of a sub-pulmonary ventricle, the Fontan circulation is sensitive to respirationinduced changes in intrathoracic pressure. However, the importance of a 'respiratory pump' in creating forward flow remains controversial. We aimed at evaluating the effect of respiration on ventricular filling during exercise using clinical data and computational modeling predictions. Methods: Ten Fontan patients (6 male, 20±4 years) underwent ungated cardiac magnetic resonance (CMR) imaging at rest and during supine bicycle exercise to evaluate systemic ventricular volumes (end-diastolic volume index (EDVi), end-systolic volume index (ESVi) and stroke volume index (SVi)) during no..
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Funding Acknowledgements
We would like to thank Rotary Club of Tienen, Sporta monVentoux and Eddy Merckx research grant for donating toward the cost of the CMR-compatible ergometer. A La Gerche was supported by a grant from the National Health and Medical Research Council (NHMRC) of Australia. Drs Marsden and Kung were supported by the Leducq Foundation and by a Burroughs Wellcome Fund CASI award.