Journal article
A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease
W Khan, V Giampietro, T Banaschewski, GJ Barker, ALW Bokde, C Büchel, P Conrod, H Flor, V Frouin, H Garavan, P Gowland, A Heinz, B Ittermann, H Lemaître, F Nees, T Paus, Z Pausova, M Rietschel, MN Smolka, A Ströhle Show all
Journal of Alzheimer S Disease | IOS PRESS | Published : 2017
DOI: 10.3233/JAD-161097
Abstract
The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n 1,781), we compared the effect of APOE and amyloid-β (Aβ) on baseline hippocampal volumes in AD patients, mild cognitive impairment (MCI) subjects, and healthy controls. A large sample of healthy adolescents (n 1,387) was also used to compared hippocampal volumes between APOE groups. Subjects had undergone a magnetic resonance imaging (MRI) scan and APOE genotyping. Hippocampal volumes were processed using FreeSurfer. In the AD and normal aging dataset, hippocampal comparisons were pe..
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Awarded by European Commission
Funding Acknowledgements
Data used in the preparation of this study was obtained from the AddNeuroMed study which was supported by InnoMed, (Innovative Medicines in Europe) an Integrated Project funded by the European Union of the Sixth Framework program priority FP6-2004-LIFESCIHEALTH-5, Life Sciences, Genomics and Biotechnology for Health, Health Research Council of Academy of Finland (HS), The Gamla Tjanarinnor Foundation, The Swedish Alzheimer's Association and Swedish Brain Power.r Data used in the preparation of this study were obtained from the Swedish National Study of Aging and Care in Kungsholmen (SNAC-K) which was supported by Stiftelsen for Gamla Tjanarinnor and Sigurd och Elsa Goljes Minne, the Swedish Research Council, the Swedish Council for Working Life and Social Research, Swedish Brain Power, an Alexander von Humboldt Research Award, and a donation from the af Jochnick Foundation.r Data used in the preparation of this study were obtained for the IMAGEN study which was supported by the IMAGEN project, which receives research funding from the European Community's Sixth Framework Program (LSHM-CT-2007-037286) and coordinated project ADAMS (242257), as well as the NIHR Biomedical Research Centre for Mental Health and NIHR Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology, and Neuroscience (IoPPN), King's College London, Alzheimer Research UK and the IMI funded European Medical Information Framework.