The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development
Sarah K Harten, Timothy J Bruxner, Vandhana Bharti, Marnie Blewitt, Nguyen Thi-My-Tam, Emma Whitelaw, Trevor Epp
Mammalian Genome | SPRINGER | Published : 2014
An ENU mutagenesis screen to identify novel epigenetic modifiers was established in mice carrying a multi-copy GFP transgene, which is expressed in a variegated manner in erythrocytes and is highly sensitive to epigenetic silencing. The screen has produced mouse mutants of both known modifiers of epigenetic state, such as Dnmt1 and Smarca5, and novel modifiers, such as Smchd1 and Rlf. Here we report two mouse lines generated from the screen, MommeD6 and MommeD20, with point mutations in D14Abb1e. These are the first mouse mutants of D14Abb1e (also known as Fam208a), a gene about which little is known. Heterozygous intercrosses show that homozygous mutants from both the MommeD6 and MommeD20 l..View full abstract
This study was supported by the National Health and Medical Research Council of Australia Grants to SKH and EW.