Journal article

Predicting the release profile of small molecules from within the ordered nanostructured lipidic bicontinuous cubic phase using translational diffusion coefficients determined by PFG-NMR

Thomas G Meikle, Shenggen Yao, Alexandru Zabara, Charlotte E Conn, Calum J Drummond, Frances Separovic



The ordered nanostructured lipidic bicontinuous cubic phase has demonstrated potential as a drug release material, due to its ability to encapsulate a wide variety of compounds, which may undergo sustained, diffusion controlled release over time. Control of drug release has been shown to depend on the nanostructural parameters of the lipid mesophase. Herein, the diffusion and release of two amino acids, encapsulated within a range of different lipidic cubic mesophases are investigated. Pulsed-field gradient NMR was used to determine the diffusion coefficient of the encapsulated amino acid, which was found to be correlated with the nanoscale diameter of the water channels within the cubic mes..

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Awarded by ARC DECRA Fellowship

Funding Acknowledgements

The authors wish to thank the Centre for Molecular and Nanoscale Physics, School of Applied Sciences, RMIT University, particularly Matt Taylor and Reece Nixon-Luke for their assistance with small angle X-ray scattering experiments. T. G. M. was the recipient of a CSIRO-Melbourne Research Scholarship. C. E. C. is the recipient of an ARC DECRA Fellowship DE160101281.