Journal article
The asymmetric cell division regulators par3, scribble and PINS/GPSM2 are not essential for erythroid development or enucleation
CB Wölwer, N Gödde, LB Pase, IA Elsum, KYB Lim, F Sacirbegovic, CR Walkley, S Ellis, S Ohno, F Matsuzaki, SM Russell, PO Humbert
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Erythroid enucleation is the process by which the future red blood cell disposes of its nucleus prior to entering the blood stream. This key event during red blood cell development has been likened to an asymmetric cell division (ACD), by which the enucleating erythroblast divides into two very different daughter cells of alternate molecular composition, a nucleated cell that will be removed by associated macrophages, and the reticulocyte that will mature to the definitive erythrocyte. Here we investigated gene expression of members of the Par, Scribble and Pins/Gpsm2 asymmetric cell division complexes in erythroid cells, and functionally tested their role in erythroid enucleation in vivo an..
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Funding Acknowledgements
The studies presented here were supported by the Peter MacCallum Cancer Foundation and a grant from the National Health and Medical Research Council of Australia (NHMRC). CBW was supported by the Australian Postgraduate Award (APA). POH and SMR were supported by a Senior Research Fellowship from the NHMRC.