Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
ACS NANO | AMER CHEMICAL SOC | Published : 2017
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in immunology and biotechnology over the past few decades have facilitated a shift from empirical to rational vaccine design, opening possibilities for improved vaccines. Some of the most important advancements include (i) the purification of subunit antigens with high safety profiles, (ii) the identification of innate pattern recognition receptors (PRRs) and cognate agonists responsible for inducing immune responses, and (iii) developments in nano- and..View full abstract
Related Projects (2)
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by ARC under the Australian Laureate Fellowship scheme
This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship scheme (F.C., FL120100030).