Pleiotropic Effects of Loss of the D alpha 1 Subunit in Drosophila melanogaster: Implications for Insecticide Resistance
Jason Somers, Ngoc Bao Luong Hang, Judith Mitchell, Philip Batterham, Trent Perry
Genetics | Genetics Society of America | Published : 2017
Nicotinic acetylcholine receptors (nAChRs) are a highly conserved gene family that form pentameric receptors involved in fast excitatory synaptic neurotransmission. The specific roles individual nAChR subunits perform in Drosophila melanogaster and other insects are relatively uncharacterized. Of the 10 D. melanogaster nAChR subunits, only three have described roles in behavioral pathways; Dα3 and Dα4 in sleep, and Dα7 in the escape response. Other subunits have been associated with resistance to several classes of insecticides. In particular, our previous work has demonstrated that an allele of the Dα1 subunit is associated with resistance to neonicotinoid insecticides. We used ends-out gen..View full abstract
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Awarded by Australian Research Council Discovery Project
The authors thank Bruno van Swinderen for valuable discussions and the loan of DAM2 equipment. This research was funded through an Australian Research Council Discovery Project (DP130102415) awarded to PB.