Journal article

Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-beta Activity

Yuxiu C Xia, Asmaa Radwan, Christine R Keenan, Shenna Y Langenbach, Meina Li, Danica Radojicic, Sarah L Londrigan, Rosa C Gualano, Alastair G Stewart



Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are commonly associated with respiratory syncytial virus (RSV), rhinovirus (RV) and influenza A virus (IAV) infection. The ensuing airway inflammation is resistant to the anti-inflammatory actions of glucocorticoids (GCs). Viral infection elicits transforming growth factor-β (TGF-β) activity, a growth factor we have previously shown to impair GC action in human airway epithelial cells through the activation of activin-like kinase 5 (ALK5), the type 1 receptor of TGF-β. In the current study, we examine the contribution of TGF-β activity to the GC-resistance caused by viral infection. We demonstrate that viral infection of h..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by University of Melbourne (UoM)

Awarded by NHMRC

Funding Acknowledgements

This work was supported by: National Health and Medical Research Council (NHMRC) research grant ( APP1059665 to AGS, The University of Melbourne Early Career Researcher Grant (UoM ECR) ( APP602017 to YCX, and the NHMRC Peter Doherty-Australian Biomedical Fellowship APP1072108 to YCX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.