Genomic Insights into a Sustained National Outbreak of Yersinia pseudotuberculosis
Deborah A Williamson, Sarah L Baines, Glen P Carter, Anders Goncalves da silva, Xiaoyun Ren, Jill Sherwood, Muriel Dufour, Mark B Schultz, Nigel P French, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
GENOME BIOLOGY AND EVOLUTION | OXFORD UNIV PRESS | Published : 2016
In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across all major cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here, we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide dis..View full abstract
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Awarded by National health and Medical Research Council (NHMRC), Australia
We thank staff in the Enteric Reference Laboratory and Health Intelligence Team at the Institute of Environmental Science and Research, New Zealand. We thank Public Health Units, laboratories and clinicians throughout New Zealand. We also thank the New Zealand Ministry of Health. Sequencing work was partially funded by the New Zealand Ministry of Health. Doherty Applied Microbial Genomics is funded by the Department of Microbiology and Immunology at The University of Melbourne. The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Department of Health and Human Services, Victoria. BPH is funded by a Fellowship from the National health and Medical Research Council (NHMRC), Australia (GNT1105905).