Copper binding and redox chemistry of the A beta 16 peptide and its variants: insights into determinants of copper-dependent reactivity
Nineveh Yako, Tessa R Young, Jade M Cottam Jones, Craig A Hutton, Anthony G Wedd, Zhiguang Xiao
METALLOMICS | ROYAL SOC CHEMISTRY | Published : 2017
The metal-binding sites of Aβ peptides are dictated primarily by the coordination preferences of the metal ion. Consequently, Cu(i) is typically bound with two His ligands in a linear mode while Cu(ii) forms a pseudo-square planar stereochemistry with the N-terminal amine nitrogen acting as an anchoring ligand. Several distinct combinations of other groups can act as co-ligands for Cu(ii). A population of multiple binding modes is possible with the equilibrium position shifting sensitively with solution pH and the nature of the residues in the N-terminal region. This work examined the Cu(ii) chemistry of the Aβ16 peptide and several variants that targeted these binding modes. The results are..View full abstract
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Awarded by Australian Research Council
This work was supported by funding from the Australian Research Council Grant DP130100728. We thank Prof. Ashley Bush for comments and discussions and Mrs Sioe See Volaric for providing technical support for recording EPR spectra.