Journal article

Copper binding and redox chemistry of the A beta 16 peptide and its variants: insights into determinants of copper-dependent reactivity

Nineveh Yako, Tessa R Young, Jade M Cottam Jones, Craig A Hutton, Anthony G Wedd, Zhiguang Xiao

Metallomics | ROYAL SOC CHEMISTRY | Published : 2017

DOI: 10.1039/c6mt00299d

Related Projects (1)

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How does Redox Cycling Drive the Metabolism of the Essential Metals Iron and Copper?

Iron and copper are essential metal nutrients but mishandling leads to cardiovascular, metabolic and neurological disease. Intriguingly, som..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by funding from the Australian Research Council Grant DP130100728. We thank Prof. Ashley Bush for comments and discussions and Mrs Sioe See Volaric for providing technical support for recording EPR spectra.

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Keywords

Science & Technology
A-Beta
Oxidative Stress
Amyloid-Beta Peptide
Electron Spin Resonance Spectroscopy
Cu(ii) Binding
Biological Function
Hydrogen-Peroxide
Biochemistry & Molecular Biology
Protein Binding
Amyloid Beta-Peptides
Life Sciences & Biomedicine
Ascorbic Acid
Hydrogen-Ion Concentration
Oxidation-Reduction
Precursor Protein
Pseudomonas-Syringae
Active Metal-Ions
Copper
Humans
Oxygen
Alzheimers-Disease