Journal article

Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-alpha-1,2-Mannanase

Marija Petricevic, Lukasz F Sobala, Pearl Z Fernandes, Lluis Raich, Andrew J Thompson, Ganeko Bernardo-Seisdedos, Oscar Millet, Sha Zhu, Matthieu Sollogoub, Jesus Jimenez-Barbero, Carme Rovira, Gideon J Davies, Spencer J Williams

Journal of the American Chemical Society | AMER CHEMICAL SOC | Published : 2017

University of Melbourne Researchers


Awarded by Australian Research Council

Awarded by BBSRC

Awarded by ERC

Awarded by Spanish Ministry of Economy and Competitiveness

Awarded by Generalitat de Catalunya

Awarded by Biotechnology and Biological Sciences Research Council

Funding Acknowledgements

We thank the Australian Research Council (FT130100103; DP120101396), the BBSRC (BB/G016127/1) and the ERC (ERC-2012-AdG-322942), the Spanish Ministry of Economy and Competitiveness (CTQ2014-55174, CTQ2015-64597-C2-1P, CTQ2015-68756-R) and the Generalitat de Catalunya (2014SGR-987). We thank Diamond Light Source for access to beamlines i02, i04,i04-1, and i24 (mx-9948) that contributed to the results presented here. We are grateful to Sivanandam Veeramuthu for his help with NMR. In-house crystal screening and testing was performed on X-ray equipment provided, in part, by the Wellcome Trust. The authors gratefully acknowledge the computer resources at MareNostrum and the technical support provided by BSC-CNS (RES-QCM-2016-3-00017). L.R. thanks the University of Barcelona for an APIF predoctoral fellowship.