Journal article
Characterising private and shared signatures of positive selection in 37 Asian populations
X Liu, D Lu, WY Saw, PJ Shaw, P Wangkumhang, C Ngamphiw, S Fucharoen, W Lert-Itthiporn, K Chin-Inmanu, TNB Chau, K Anders, A Kasturiratne, HJ De Silva, T Katsuya, R Kimura, T Nabika, T Ohkubo, Y Tabara, F Takeuchi, K Yamamoto Show all
European Journal of Human Genetics | SPRINGERNATURE | Published : 2017
Abstract
The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple po..
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Awarded by National University of Singapore
Funding Acknowledgements
We thank all the subjects in this study for their participation. YYT acknowledges the support of the Saw Swee Hock School of Public Health, the National University Health System and the Life Sciences Institute from the National University of Singapore. SX acknowledges financial support from the National Natural Science Foundation of China (91331204 and 31525014), the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (QYZDJ-SSW-SYS009), and the Program of Shanghai Academic Research Leader (16XD1404700). ST acknowledges support from the Thailand Research Fund mid-career search grant RSA5860081.