Journal article
PROX1gene CC genotype as amajor determinant of early onset of type 2 diabetes in slavic study participants from Action in Diabetes andVascular Disease: Preterax and Diamicron MR Controlled Evaluation study
P Hamet, M Haloui, F Harvey, FC Marois-Blanchet, MP Sylvestre, MR Tahir, PHG Simon, BS Kanzki, J Raelson, C Long, J Chalmers, M Woodward, M Marre, S Harrap, J Tremblay
Journal of Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Background: The prevalence of diabetic nephropathy varies according to ethnicity. Environmental as well as genetic factors contribute to the heterogeneity in the presentation of diabetic nephropathy. Our objective was to evaluate this heterogeneity within the Caucasian population. Methods: The geo-ethnic origin of the 3409 genotyped Caucasian type 2 diabetes (T2D) patients of Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation was determined using principal component analysis. Genome-wide association studies analyses of age of onset of T2D were performed for geoethnic groups separately and combined. Results: The first principal component separated the Cau..
View full abstractGrants
Funding Acknowledgements
The authors acknowledge the support of grant OPTI-THERA, a private-public initiative of Government of Quebec in 'Optimization of Therapeutic Approaches in Personalized Primary Care.' The project is financed by the 'Fond de Partenariat pour un Quebec Innovant et en Sante' from the Ministry of Economic Development, Innovation and Export Trade with additional funding from Canadian Institutes of Health Research, Genome Quebec, Servier Canada and Les Laboratoires Servier, Paris, France.