Journal article

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

Laurence D Hurst, Avazeh T Ghanbarian, Alistair RR Forrest, Lukasz Huminiecki

PLOS Biology | PUBLIC LIBRARY SCIENCE | Published : 2015


X chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline. Here, we examine the notion that, at least in some taxa, functionally biased gene content may more profoundly be shaped by limits imposed on gene expression owing to haploid expression of the X chromosome. Notably, if the X, as in primates, is transcribed at rates comparable to the ancestral rate (per promoter) prior to the X chromosome formation, then the X is not a tolerable environment for genes with very high maximal net levels of expression, owing to transcript..

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Awarded by Vetenskapsradet's project

Awarded by European Research Council

Awarded by Medical Research Council

Funding Acknowledgements

FANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to YH and a Grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to YH. Vetenskapsradet's project grant 2011-5893 funded LH. European Research Council's grant (ERC-2014-ADG 669207) supports LDH. LDH would also like to acknowledge a Medical Research Council's award MR/L007215/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.