Journal article
High incidence of contaminating maternal cell overgrowth in human placental mesenchymal stem/stromal cell cultures: A systematic review
CF Heazlewood, H Sherrell, J Ryan, K Atkinson, CA Wells, NM Fisk
Stem Cells Translational Medicine | WILEY | Published : 2014
Abstract
Placenta is a readily accessible translationally advantageous source of mesenchymal stem/stromal cells (MSCs) currently used in cryobanking and clinical trials. MSCs cultured from human chorion have been widely assumed to be fetal in origin, despite evidence that placental MSCs maybe contaminated with maternal cells, resulting in entirely maternally derivedMSCcultures. To document the frequency and determinants of maternal cell contamination in chorionic MSCs, we undertook a PRISMAcompliant systematic review of publications in the PubMed, Medline, and Embase databases (January 2000 to July 2013) on placental and/or chorionic MSCs from uncomplicated pregnancies. Of 147 studies, only 26 (18%) ..
View full abstractGrants
Funding Acknowledgements
This work was funded by a philanthropic donation from the JEM Research Foundation, Australia (to C.A.W.) and by the Australian Research Council Special Research Initiative in Stem Cell Sciences to Stem Cells Australia (to C.A.W.). C.A.W. is supported by a Queensland Smart Futures Fellowship from the Queensland Government.