Journal article
Structural and physiological neurovascular changes in idiopathic Parkinson’s disease and its clinical phenotypes
S Al-Bachari, R Vidyasagar, HCA Emsley, LM Parkes
Journal of Cerebral Blood Flow and Metabolism | SAGE PUBLICATIONS INC | Published : 2017
Abstract
Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson’s disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN). Fifty-one patients with IPD (mean age 69.0 ± 7.7 years) (21 tremor dominant (TD), 24 postural instability and gait disorder (PIGD) and..
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Awarded by Medical Research Council
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Salary (Dr Al-Bachari) and research costs for this work were provided through support from: Sydney Driscoll Neuroscience Foundation; University of Manchester (Biomedical Imaging Institute) and Medical Research Council Studentship; Lancashire Teaching Hospitals NHS Foundation Trust & Lancaster University. Dr Vidyasagar is supported by the University of Melbourne. Dr Emsley is supported by Lancashire Teaching Hospitals NHS Foundation Trust. Dr Parkes is supported by the University of Manchester.