Journal article
Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease
CY Chan, A Noor, CA McLean, PS Donnelly, PJ Barnard
Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2017
DOI: 10.1039/c6cc10066j
Abstract
A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.
Grants
Awarded by Australian Research Council
Funding Acknowledgements
This work has been supported by the Australian Research Council (DP150102741) and the La Trobe University Understanding Disease Research Focus Area. The Victorian Brain Bank Network is acknowledged for the provision of human brain tissue.