Journal article

The diminishing dominance of the dominant hemisphere: Language fMRI in focal epilepsy

Chris Tailby, David F Abbott, Graeme D Jackson



"Which is the dominant hemisphere?" is a question that arises frequently in patients considered for neurosurgery. The concept of the dominant hemisphere implies uniformity of language lateralisation throughout the brain. It is increasingly recognised that this is not the case in the healthy control brain, and it is especially not so in neurological diseases such as epilepsy. In the present work we adapt our published objective lateralisation method (based on the construction of laterality curves) for use with sub-lobar cortical, subcortical and cerebellar regions of interest (ROIs). We apply this method to investigate regional lateralisation of language activation in 12 healthy controls and ..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC Practitioner Fellowship

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (grants no. 1081151 and 1091593). DFA is supported by fellowship funding from the Australian National Imaging Facility. GDJ is supported by an NHMRC Practitioner Fellowship (grant no. 1060312). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.