Opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size: phenotypic support for hypothesized diametric gene-dosage effects
Sean G Byars, Stephen C Stearns, Jacobus J Boomsma
Proceedings of the Royal Society B | ROYAL SOC | Published : 2014
Opposite phenotypic and behavioural traits associated with copy number variation and disruptions to imprinted genes with parent-of-origin effects have led to the hypothesis that autism and schizophrenia share molecular risk factors and pathogenic mechanisms, but a direct phenotypic comparison of how their risks covary has not been attempted. Here, we use health registry data collected on Denmark's roughly 5 million residents between 1978 and 2009 to detect opposing risks of autism and schizophrenia depending on normal variation (mean ± 1 s.d.) in adjusted birth size, which we use as a proxy for diametric gene-dosage variation in utero. Above-average-sized babies (weight, 3691-4090 g; length,..View full abstract
Awarded by Danish National Research Foundation
Awarded by Marie Curie International Incoming Fellowship
The Centre for Social Evolution and its Evolutionary Medicine programme are funded by the Danish National Research Foundation (DNRF57). S. G. B. was also funded by a Marie Curie International Incoming Fellowship FP7-PEOPLE-2010-IIF-276565.