Journal article
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease
L Le Texier, KE Lineburg, B Cao, C McDonald-Hyman, LLE Mouttie, J Nicholls, M Melino, BC Nalkurthi, KA Alexander, B Teal, SJ Blake, F Souza-Fonseca-Guimaraes, CR Engwerda, RD Kuns, SW Lane, M Teng, C Teh, D Gray, AD Clouston, SK Nilsson Show all
Jci Insight | AMER SOC CLINICAL INVESTIGATION INC | Published : 2016
Abstract
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD), a serious complication of allogeneic stem cell transplantation (SCT). We recently reported increased expression of autophagy-related genes (Atg) in association with enhanced survival of Tregs after SCT. Autophagy is a self-degradative process for cytosolic components that promotes cell homeostasis and survival. Here, we demonstrate that the disruption of autophagy within FoxP3+ Tregs (B6.Atg7fl/fl-FoxP3cre+) resulted in a profound loss of Tregs, particular..
View full abstractGrants
Awarded by National Institute of Allergy and Infectious Diseases