Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Dinh S Bui, John A Burgess, Adrian J Lowe, Jennifer L Perret, Caroline J Lodge, Bui Minh, Stephen Morrison, Bruce R Thompson, Paul S Thomas, Graham G Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AMER THORACIC SOC | Published : 2017
RATIONALE: The burden of chronic obstructive pulmonary disease (COPD) is increasing, yet there are limited data on early life risk factors. OBJECTIVES: To investigate the role of childhood lung function in adult COPD phenotypes. METHODS: Prebronchodilator spirometry was performed for a cohort of 7-year-old Tasmanian children (n = 8,583) in 1968 who were resurveyed at 45 years, and a selected subsample (n = 1,389) underwent prebronchodilator and post-bronchodilator spirometry. For this analysis, COPD was spirometrically defined as a post-bronchodilator FEV1/FVC less than the lower limit of normal. Asthma-COPD overlap syndrome (ACOS) was defined as the coexistence of both COPD and current asth..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant scheme
Awarded by NHMRC European collaborative grant scheme as part of ALEC (Ageing Lungs in European Cohorts) - European Union's Horizon 2020 research and innovation programme
Supported by the National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant scheme (299901 and 1021275) and NHMRC European collaborative grant scheme (1101313) as part of ALEC (Ageing Lungs in European Cohorts), funded by the European Union's Horizon 2020 research and innovation programme under grant 633212; The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland, and Tasmanian Asthma Foundations; The Royal Hobart Hospital; Helen MacPherson Smith Trust; and GlaxoSmithKline. The funding agencies had no direct role in the conduct of the study; the collection, management, statistical analysis, or interpretation of the data; or preparation or approval of the manuscript.