Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?
Kate A McBride, Mandy L Ballinger, Timothy E Schlub, Mary-Anne Young, Martin HN Tattersall, Judy Kirk, Ros Eeles, Emma Killick, Leslie G Walker, Sue Shanley, David M Thomas, Gillian Mitchell
Familial Cancer | SPRINGER | Published : 2017
Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers of WB-MRI screening as part of the Surveillance in Multi-Organ Cancer (SMOC+) protocol, measuring their unmet needs, anxiety and depression levels as well as cancer worry using psychological questionnaires and in-depth interviews about their experiences of screening. We present preliminary psychosocial findings from 17 participants during their first 12 months on the trial. We found a significant reduction in participants' mean anxiety from baseline to two weeks post WB-MR..View full abstract