Journal article
Electrical stimulation using conductive polymer polypyrrole counters reduced neurite outgrowth of primary prefrontal cortical neurons from NRG1-KO and DISC1-LI mice
Q Zhang, D Esrafilzadeh, JM Crook, R Kapsa, EM Stewart, E Tomaskovic-Crook, GG Wallace, XF Huang
Scientific Reports | NATURE PORTFOLIO | Published : 2017
DOI: 10.1038/srep42525
Abstract
Deficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1 (NRG1) and disrupted in schizophrenia 1 (DISC1) have been implicated in psychiatric disorders including schizophrenia. Electrical stimulation using conductive polymers has been shown to stimulate neurite outgrowth of differentiating human neural stem cells. This study investigated the use of the electroactive conductive polymer polypyrrole (Ppy) to counter impaired neurite outgrowth of primary pre-frontal cortical (PFC) neurons from NRG1-knock out (NRG1-KO) and DISC1-locus impairment (DISC1-LI) mice. Whereas NRG1-KO and DISC1-LI exhibited reduced neurite length and number of neurite branches compared t..
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Awarded by Australian National Fabrication Facility
Funding Acknowledgements
The authors wish to acknowledge funding from the Australian National Health and Medical Research Council (NHMRC: APP106543), Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012), and support of the Australian National Fabrication Facility (ANFF) - Materials Node. Professor Gordon Wallace acknowledges the support of the ARC through an ARC Laureate Fellowship (FL110100196) (We thank Prof Sawa and Dr. Jaaro-Peled for providing us with the original DISC1-LI mutant mice).