Journal article
Mineral adaptations following kidney transplantation
SJ Tan, A Crosthwaite, D Langsford, V Obeysekere, FL Ierino, MA Roberts, PD Hughes, TD Hewitson, KM Dwyer, ND Toussaint
Transplant International | WILEY | Published : 2017
DOI: 10.1111/tri.12925
Abstract
Klotho is predominantly expressed in the kidney and reported to have antioxidant and antifibrotic properties. Soluble Klotho (sKl), the circulating protein cleaved from membrane-bound Klotho, is reduced significantly with kidney disease and inversely associated with mortality. sKl has not been thoroughly evaluated prospectively after kidney transplantation. Incident kidney transplant recipients (KTRs) were prospectively evaluated pretransplantation, 1, 12 and 52 weeks post-transplantation. Basic biochemistry, sKl and intact FGF23 were measured. Within-subject comparisons were evaluated using repeat-measure anova or Friedman's analysis. Effects of immunosuppression and biochemical parameters ..
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Funding Acknowledgements
SJT is a current recipient of a National Health and Medical Research Council (NHMRC) Postgraduate Research Scholarship. NDT is supported by a Jacquot Foundation Research Establishment Award. The contents of this article are solely the views of the individual authors and do not reflect the views of NHMRC or the Jacquot Foundation.