Journal article

Musculoskeletal decline and mortality: prospective data from the Geelong Osteoporosis Study

Julie A Pasco, Mohammadreza Mohebbi, Kara L Holloway, Sharon L Brennan-Olsen, Natalie K Hyde, Mark A Kotowicz



BACKGROUND: We aimed to examine the relationship between musculoskeletal deterioration and all-cause mortality in a cohort of women studied prospectively over a decade. METHODS: A cohort of 750 women aged 50-94 years was followed for a decade after femoral neck bone mineral density (BMD) and appendicular lean mass (ALM) were measured using dual energy X-ray absorptiometry, in conjunction with comorbidities, health behaviour data, and other clinical measures. The outcome was all-cause mortality identified from the Australian National Deaths Index. Using Cox proportional hazards models and age as the time variable, mortality risks were estimated according to BMD groups (ideal-BMD, osteopenia, ..

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Awarded by National Health and Medical Research Council (NHMRC) Australia

Awarded by NHMRC

Funding Acknowledgements

The study was funded by the Victorian Health Promotion Foundation and the National Health and Medical Research Council (NHMRC) Australia (projects 251638 and 628582), but they played no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; nor in the decision to submit the paper for publication. K.L.H. is supported by an Alfred Deakin Postdoctoral Research Fellowship, S.L.B.-O. by NHMRC Career Development Fellowship (1107510), and N.K.H. by an Australian Postgraduate Award. The authors certify that they comply with the ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015.<SUP>39</SUP>