5-HT2A Agonists: A Novel Therapy for Functional Neurological Disorders?
Alexander Bryson, Olivia Carter, Trevor Norman, Richard Kanaan
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2017
Functional neurological disorders are frequently encountered in clinical practice. They have a poor prognosis and treatment options are limited. Their etiology is unknown, but leading theories propose a disturbance of somatic self-representation: the mind perceives dysfunction of a body region despite intact motor and sensory pathways. Central to this model is the concept of an abnormal top-down cognitive influence upon sensorimotor function. There is growing interest in the use of 5-HT2A agonists in the management of neuropsychiatric conditions. Recent studies have shown that these agents induce changes in neural activity that disrupt hierarchical brain dynamics and modulate networks subser..View full abstract