Journal article

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

Holly AF Stessman, Bo Xiong, Bradley P Coe, Tianyun Wang, Kendra Hoekzema, Michaela Fenckova, Malin Kvarnung, Jennifer Gerdts, Sandy Trinh, Nele Cosemans, Laura Vives, Janice Lin, Tychele N Turner, Gijs Santen, Claudia Ruivenkamp, Marjolein Kriek, Arie van Haeringen, Emmelien Aten, Kathryn Friend, Jan Liebelt Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2017

Grants

Awarded by Simons Foundation Autism Research Initiative


Awarded by NIH


Awarded by Netherlands Organization for Scientific Research


Awarded by Horizon 2020 Marie SklodowskaCurie European Training Network (MiND)


Awarded by NHGRI Interdisciplinary Training in Genome Science grant


Awarded by Australian NHMRC


Awarded by National Basic Research Program of China


Awarded by National Natural Science Foundation of China


Awarded by China Scholarship Council


Awarded by Fundamental Research Funds for the Central Universities


Awarded by National Health and Medical Research Council of Australia


Awarded by University of California, San Diego Clinical and Translational Research Institute


Awarded by National Institute of Mental Health


Funding Acknowledgements

We thank the individuals and their families for participation in this study. We acknowledge the Vienna Drosophila Resource Center and Bloomington Drosophila Stock Center (NIH P40OD018537). This research was supported in part by the following: the Simons Foundation Autism Research Initiative (SFARI 303241) and NIH (R01MH101221) to E.E.E.; VIDI and TOP grants (917-96-346, 912-12-109) from the Netherlands Organization for Scientific Research and Horizon 2020 Marie SklodowskaCurie European Training Network (MiND, 643051) to A.S.; an NHGRI Interdisciplinary Training in Genome Science grant (T32HG00035) to H.A.F.S. and T.N.T.; Australian NHMRC grants 1091593 and 1041920 and Channel 7 Children's Research Foundation support to J.G.; the National Basic Research Program of China (2012CB517900) and the National Natural Science Foundation of China (81330027, 81525007 and 31400919) to K.X.; the China Scholarship Council (201406370028) and the Fundamental Research Funds for the Central Universities (2012zzts110) to T.W.; National Health and Medical Research Council of Australia Project grants (556759 and 1044175) to I.E.S., P.J.L., and M.B.D., and a Practitioner Fellowship (1006110) to I.E.S.; grants from the Jack Brockhoff Foundation and Perpetual Trustees, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS, the Swedish Brain Foundation, the Swedish Research Council, and the Stockholm County Council; the University of California, San Diego Clinical and Translational Research Institute (KL2TR00099 and 1KL2TR001444) to T.P.; and the Research FundFlanders (FWO) to R.F.K. and G.V.D.W. We are grateful to all of the families at the participating SSC sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). We appreciate access to phenotypic data on SFARI Base. We gratefully acknowledge the resources provided by the Autism Genetic Resource Exchange (AGRE) Consortium and the participating AGRE families. AGRE is a program of Autism Speaks and is supported in part by grant 1U24MH081810 from the National Institute of Mental Health to C.M. Lajonchere. We thank N. Brown, K. Pereira, T. Vick, T. Desai, C. Green, A.L. Doebley, and L. Grillo for their valuable contributions as well as T. Brown for assistance in editing this manuscript. H.P. is supported as a Senior Clinical Investigator of FWO. E.E.E. is supported as an investigator of the Howard Hughes Medical Institute.