The genetic regulation of transcription in human endometrial tissue
Jenny N Fung, Jane E Girling, Samuel W Lukowski, Yadav Sapkota, Leanne Wallace, Sarah J Holdsworth-Carson, Anjali K Henders, Martin Healey, Peter AW Rogers, Joseph E Powell, Grant W Montgomery
HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2017
Study question: Do genetic effects regulate gene expression in human endometrium? Summary answer: This study demonstrated strong genetic effects on endometrial gene expression and some evidence for genetic regulation of gene expression in a menstrual cycle stage-specific manner. What is known already: Genetic effects on expression levels for many genes are tissue specific. Endometrial gene expression varies across menstrual cycle stages and between individuals, but there are limited data on genetic control of expression in endometrium. Study design, size, duration: We analysed genome-wide genotype and gene expression data to map cis expression quantitative trait loci (eQTL) in endometrium. P..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Fellowships
Research reported in this publication was supported by National Health and Medical Research Council (NHMRC) project grants GNT1026033, GNT1049472, GNT1046880, GNT1050208, GNT1105321 and APP1083405. S.J.H.-C. is supported by the J.N. Peters Bequest Fellowship (University of Melbourne). G.W.M. and J.E.P. are supported by NHMRC Fellowships (GNT1078399, APP1107599).