Journal article
Hypothermia revisited: Impact of ischaemic duration and between experiment variability
SSJ Rewell, AL Jeffreys, SA Sastra, SF Cox, JA Fernandez, E Aleksoska, HB van der Worp, L Churilov, MR Macleod, DW Howells
Journal of Cerebral Blood Flow and Metabolism | SAGE PUBLICATIONS INC | Published : 2017
Abstract
To assess the true effect of novel therapies for ischaemic stroke, a positive control that can validate the experimental model and design is vital. Hypothermia may be a good candidate for such a positive control, given the convincing body of evidence from animal models of ischaemic stroke. Taking conditions under which substantial efficacy had been seen in a meta-analysis of hypothermia for focal ischaemia in animal models, we undertook three randomised and blinded studies examining the effect of hypothermia induced immediately following the onset of middle cerebral artery occlusion on infarct volume in rats (n = 15, 23, 264). Hypothermia to a depth of 33℃ and maintained for 130 min signific..
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Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by an NHMRC-EU collaborative grant. H.B. van der Worp is supported by a grant from the Dutch Heart Foundation (2010T075).