Journal article

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew webb, Peter AB Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska Show all

ELIFE | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2017

Abstract

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COP..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

Victorian State Government, Australia Operational Infrastructure Scheme grant Lukasz Kedzierski Tatiana B Kolesnik Edmond M Linossi Laura Dagley Sarah Freeman Simon M Chatfield Jeffrey J Babon Nicholas Huntington Gabrielle Belz Andrew Webb Nicos A Nicola Sandra E Nicholson Giuseppe InfusiniNational Health and Medical Research Council IRIISS grant 361646 Lukasz Kedzierski Tatiana B Kolesnik Edmond M Linossi Laura Dagley Sarah Freeman Giuseppe Infusini Simon M Chatfield Nicholas Huntington Gabrielle Belz Andrew Webb Nicos A Nicola Sandra E Nicholson Jeffrey J BabonNational Health and Medical Research Council Fellowship Michelle D Tate Malcolm R Starkey Nicos A Nicola Katherine Kedzierska Nicholas Huntington Philip M HansbroAustralian Federal Government Australian Postgraduate Award Edmond M LinossiNational Health and Medical Research Council Project grant #1045762 Peter AB Wark Philip M HansbroNational Health and Medical Research Council Program grant #1016647 Nicos A Nicola Sandra E NicholsonAustralian Research Council Future Fellowship Gabrielle Belz