Journal article
Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
L Kedzierski, MD Tate, AC Hsu, TB Kolesnik, EM Linossi, L Dagley, Z Dong, S Freeman, G Infusini, MR Starkey, NL Bird, SM Chatfield, JJ Babon, N Huntington, G Belz, A Webb, PA Wark, NA Nicola, J Xu, K Kedzierska Show all
Elife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2017
DOI: 10.7554/eLife.20444
Abstract
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COP..
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Awarded by Australian Research Council
Funding Acknowledgements
Victorian State Government, Australia Operational Infrastructure Scheme grant Lukasz Kedzierski Tatiana B Kolesnik Edmond M Linossi Laura Dagley Sarah Freeman Simon M Chatfield Jeffrey J Babon Nicholas Huntington Gabrielle Belz Andrew Webb Nicos A Nicola Sandra E Nicholson Giuseppe InfusiniNational Health and Medical Research Council IRIISS grant 361646 Lukasz Kedzierski Tatiana B Kolesnik Edmond M Linossi Laura Dagley Sarah Freeman Giuseppe Infusini Simon M Chatfield Nicholas Huntington Gabrielle Belz Andrew Webb Nicos A Nicola Sandra E Nicholson Jeffrey J BabonNational Health and Medical Research Council Fellowship Michelle D Tate Malcolm R Starkey Nicos A Nicola Katherine Kedzierska Nicholas Huntington Philip M HansbroAustralian Federal Government Australian Postgraduate Award Edmond M LinossiNational Health and Medical Research Council Project grant #1045762 Peter AB Wark Philip M HansbroNational Health and Medical Research Council Program grant #1016647 Nicos A Nicola Sandra E NicholsonAustralian Research Council Future Fellowship Gabrielle Belz