Journal article

Anti-activated factor II assay for monitoring unfractionated heparin in children: results of the HEARTCAT study.

A Hanslik, E Kitzmüller, US Tran, K Thom, H Karapetian, N Prutsch, J Voitl, I Michel-Behnke, F Newall, C Male

J Thromb Haemost | Published : 2017


Essentials Unfractionated heparin has variable effects in children and therefore, monitoring is essential. A randomized controlled trial substudy investigating an anti-IIa assay in children was conducted. Anti-IIa values are lower in younger children, an effect more pronounced at low-dose heparin. Heparin effect on Xa and IIa is not equal, particularly in infants and after high-dose heparin. SUMMARY: Background Unfractionated heparin (UFH) is used for the prophylaxis and treatment of thrombosis in children. Laboratory monitoring of UFH is needed to prevent over-anticoagulation or under-anticoagulation. Objectives To investigate the association between UFH dose and UFH effect as monitored wit..

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University of Melbourne Researchers