Journal article
Dysarthria and broader motor speech deficits in Dravet syndrome
Samantha J Turner, Amy Brown, Marta Arpone, Vicki Anderson, Angela T Morgan, Ingrid E Scheffer
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
OBJECTIVE: To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS: Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS: Speech was characterized by imprecise articulation, abnormal nasal resonance, voice, and pitch, and prosody errors. Half of verbal patients had moderate to severely impaired conversational speech intelligibility. Oral motor impairment, motor planning/programming difficulties, and poor postural control were typical. Nonverbal individuals had intentional communication. Cognitive skills ..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC) Postgraduate Scholarship
Awarded by NHMRC Career Development Award
Awarded by Practitioner Fellowship
Awarded by NHMRC
Awarded by Senior Practitioner Fellowship
Awarded by Australian Research Council Discovery
Funding Acknowledgements
S.J.T. is supported by National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (101777), Australian National University Gowrie Scholarship, and Speech Pathology Australia Nadia Verrall Memorial Research Grant.V.A. is supported by NHMRC Senior Practitioner Fellowship (2010-2019). A.T.M. is supported by NHMRC Career Development Award (607315, 2010-2015) and Practitioner Fellowship (1105008, 2016-2020). I. E. S. is supported by NHMRC Program Grant (628952, 2011-2015;1091593,2016-2020) and Senior Practitioner Fellowship ( 1006110,2011-2015;1104831,2016-2020). The project is also supported by Australian Research Council Discovery Project (DP120100285) to A.T.M. and I.E.S.