Journal article

Sex differences in psychotomimetic-induced behaviours in rats

Andrea Gogos, Snezana Kusljic, Shane J Thwaites, Maarten van den Buuse

Behavioural Brain Research | ELSEVIER SCIENCE BV | Published : 2017


Animal model studies using equal numbers of males and females are sparse in psychiatry research. Given the marked sex differences observed in psychiatric disorders, such as schizophrenia, using both males and females in research studies is an important requirement. Thus the aim of this study was to examine sex differences in psychotomimetic-induced behavioural deficits relevant to psychosis. We therefore compared the acute effect of amphetamine or phencyclidine on locomotor activity and prepulse inhibition in adult male and female Sprague-Dawley rats. The results of this study were that: (1) amphetamine-induced distance travelled was greater in female rats than in male rats, (2) phencyclidin..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The authors gratefully acknowledge the financial support of the National Health and Medical Research Council of Australia (AG CDF ID1108098, AG ECF ID509234, AG Project ID435690, MvdB SRF ID1041895, MvdB SRF ID509156) and the Jared Purton Foundation. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant.