Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors
Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds
FRONTIERS IN MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2017
Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain related and there are currently a number of strain typing schemes based on variation in capsular polysaccharide, the major and minor fimbriae and adhesin domains of Lys-gingipain (Kgp), amongst other surface proteins. P. gingivalis can exchange chromosomal DNA between strains by natural competence and conjugation. The aim of this study was to determine the genetic variability of P. gingivalis strains sourced from international locations over a 25-year period and to determine if variability in surface virulence factors has a phylogenetic basis. Whole genome sequenc..View full abstract
Awarded by Australian National Health and Medical Research Council Project
This work was supported by the Australian Government, Department of Industry, Innovation and Science and the Australian National Health and Medical Research Council Project 1081252.