Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen

Abstract

Background Proanthocyanidin has been shown to enhance dentine collagen stability and remineralization of artificial root caries. Objectives To evaluate the effect of proanthocyanidin (PA) in combination with tri-calcium phosphate (TCP) and fluoride (F) on resistance to collagen degradation and remineralization of artificial caries lesions. Methods Demineralized root fragments (n = 75) were randomly divided into five groups based on treatments: (i) 6.5% PA, (ii) TCP + F, (iii) TCP + F + 6.5% PA, (iv) 1000 ppm fluoride (Positive control) and (v) deionized water (control). Each specimen was subjected to pH cycling at 37oC for 8 days. Lesion depth and mineral loss were evaluated using microradio..