Journal article

Neutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection

Jyh Liang Hor, William R Heath, Scott N Mueller

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Neutrophils rapidly infiltrate sites of inflammation during peripheral infection or tissue injury. In addition to their well described roles as pro-inflammatory phagocytes responsible for pathogen clearance, recent studies have demonstrated a broader functional repertoire including mediating crosstalk between innate and adaptive arms of the immune system. Specifically, neutrophils have been proposed to mediate antigen transport to lymph nodes (LN) to modulate T cell priming and to influence T cell migration to infected tissues. Using a mouse model of cutaneous herpes simplex virus type 1 (HSV-1) infection we explored potential contributions of neutrophils toward anti-viral immunity. While a ..

View full abstract

Grants

Funding Acknowledgements

We thank C. Jones, G. Davey, and M. Damtsis for technical assistance. We thank M. Hickey for providing LysM-EGFP mice, and W. Gao, Y.-H. Lin, and T. Stinear for assistance and provision of S. aureus. Supported by National Health and Medical Research Council of Australia and the Australian Research Council.